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Drosophila melanogaster

ABSTRACT: Gene expression analysis of Drosophila melanogaster S2 cells after RNAi-mediated depletion of the insulator factor CTCF

OTHER RELATED OMICS DATASETS IN: GSE12765

PROVIDER: PRJNA114127 | ENA |

REPOSITORIES: ENA

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Drosophila melanogaster

Project description:Gene expression analysis of Drosophila melanogaster S2 cells after RNAi-mediated depletion of the insulator factor CP190

| PRJNA114125 | ENA

Gene expression analysis of Drosophila melanogaster S2 cells after RNAi-mediated depletion of the insulator factor CTCF

Project description:We analyzed transcriptional effects after depletion of Drosophila melanogaster S2 cells from CTCF via specific dsRNA treatment in comparison to cells treated with control dsRNA.

2009-02-21 | GSE12719 | GEO

Genome-wide study of the MSL1 effect on gene expression in Drosophila melanogaster

Project description:Measurement of gene expression by strand specific RNA-Seq in male (S2) Drosophila melanogaster cells upon depletion of MSL1 by dsRNA compared to the eGFP RNAi control.

2016-05-05 | E-MTAB-3434 | biostudies-arrayexpress

RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function

Project description:Chromatin insulators and Polycomb group (PcG) complexes control nuclear organization to effect changes in gene expression. In Drosophila, RNA silencing pathways influence long range interactions mediated by PcG proteins and nuclear localization of the gypsy insulator; however, the underlying mechanisms are unknown. Here, we identify a singular requirement for Argonaute2 (AGO2) for the activity of the CCCTC-binding factor (CTCF)/Centrosomal protein 190 (CP190) dependent Fab-8 insulator. AGO2 and CP190 interact physically, and genome wide localization of AGO2 by chromatin immunoprecipitation and sequencing (ChIP-seq) reveals extensive colocalization of AGO2 with insulators and Polycomb Response Elements (PREs) but minimal overlap with regions of endogenous small interfering RNA (endo-siRNA) production. Finally, depletion of either CTCF or CP190 results in loss of AGO2 association with insulators, PREs, and other cis-regulatory regions. Our findings suggest that Dicer-independent recruitment of AGO2 to chromatin by insulator proteins promotes the definition of transcriptional domains throughout the genome. ChIP-seq of AGO2 in two Drosophila cell types (S2 and S3)

2011-08-15 | E-GEOD-22623 | biostudies-arrayexpress

Genome wide distribution of gammaH2AvD in Wild Type and RNAi dH1 Drosophila melanogaster S2 cells

Project description:Genome wide distribution of gammaH2AvD in Wild Type and RNAi dH1 Drosophila melanogaster S2 cells

2020-07-01 | GSE76912 | GEO

CTCF/CP190 and ISWI dependent regulation of nucleosome occupancy [MNase-seq]

Project description:MNase-seq was performed in order to analyze changes in nucleosomal occupancy after depletion of CTCF/P190 and ISWI from Drosophila S2 cells MNase-seq from Drosophila S2 nuclei after CTCF/CP190 or ISWI-specific RNAi treatment

2014-08-11 | E-GEOD-51599 | biostudies-arrayexpress

CTCF/CP190 and ISWI dependent regulation of nucleosome occupancy [ChIP-seq]

Project description:H3-ChIP-seq was performed in order to analyze changes in nucleosomal occupancy after depletion of CTCF/P190 and ISWI from Drosophila S2 cells Histone H3 ChIP-seq from Drosophila S2 cells after CTCF/CP190 or ISWI-specific RNAi treatment

2014-08-11 | E-GEOD-51598 | biostudies-arrayexpress

Transcriptional profiling of Drosophila melanogaster cell lines S2 and Kc with Nup153 RNAi-mediated depletion.

Project description:Expression profiling of Nup153 RNAi-mediated depletion in Drosophila S2 and Kc cells. This experiment is related to experiment E-MEXP-2525.

2010-02-12 | E-MEXP-2523 | biostudies-arrayexpress

Gene expression analysis of Drosophila melanogaster S2 cells after RNAi-mediated depletion of the insulator factor CP190

Project description:We analyzed transcriptional effects after depletion of Drosophila melanogaster S2 cells from CP190 via specific dsRNA treatment in comparison to cells treated with control dsRNA.

2009-02-21 | GSE12718 | GEO

Gene expression analysis of Kc cells from Drosophila melanogaster during ecdysone treatment and CP190 knockdown

Project description:This study examines the changes in genes expression that occur in Drosophila melanogaster during the ecdysone response as well as during RNAi knockdown of the insulator protein, CP190. Analysis was performed in Kc cells after 0, 3, and 48 hours of ecdysone treatment in the presence of either control or CP190 knockdown.

2011-10-14 | GSE30686 | GEO

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