Genomics

Dataset Information

0

Plasmodium berghei


ABSTRACT: Plasmodium berghei PbeIK2KO sporozoites

ORGANISM(S): Plasmodium berghei  

PROVIDER: PRJNA115095 | ENA |

REPOSITORIES: ENA

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Publications


Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active process controlled by a eukaryotic initiation factor-2alpha (eIF2alpha) kinase (IK2) and a phosphatase. IK2 activity is dominant in salivary gland sporozoites, leading to an inhibition of translation and accumulation of stalled mRNAs into granul  ...[more]

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