Genomics

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ABSTRACT: Genome-Wide Promoter Analysis of Epigenetic Regulation by Cocaine

PROVIDER: PRJNA115545 | ENA |

REPOSITORIES: ENA

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Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings re  ...[more]

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