Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Gene expression profiles of Themis-deficient thymocytes

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA116535 | ENA |

REPOSITORIES: ENA

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Publications


T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine moti  ...[more]

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