Dataset Information


Homo sapiens

ABSTRACT: GW7647 and Rosiglitazone treated human differentiated adipocytes

ORGANISM(S): Homo sapiens  



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Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes.

Ribet Carole C   Montastier Emilie E   Valle Carine C   Bezaire Véronic V   Mazzucotelli Anne A   Mairal Aline A   Viguerie Nathalie N   Langin Dominique D  

Endocrinology 20091103 1

This work aimed at characterizing the role of peroxisome proliferator-activated receptors (PPAR)alpha in human white adipocyte metabolism and at comparing PPAR alpha and PPAR gamma actions in these cells. Primary cultures of human fat cells were treated with the PPAR alpha agonist GW7647 or the PPAR gamma agonist rosiglitazone. Changes in gene expression were determined using DNA microarrays and quantitative RT-PCR. Western blot and metabolic studies were performed to identify the biological eff  ...[more]

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