Dataset Information


Homo sapiens

ABSTRACT: Analysis of human myeloma cell lines expressing beta 3 integrin

ORGANISM(S): Homo sapiens  



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beta(3) Integrin subunit mediates the bone-resorbing function exerted by cultured myeloma plasma cells.

Tucci Marco M   De Palma Raffaele R   Lombardi Lucia L   Rodolico Gabriella G   Berrino Liberato L   Dammacco Franco F   Silvestris Franco F  

Cancer research 20090804 16

alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells from patients with no evidence of bone disease. We therefore explored the alpha(v)beta(3) transcriptional pathway in the bone-resorbing cells. Silencing of beta(3) chain abrogated th  ...[more]

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