Dataset Information


Drosophila melanogaster

ABSTRACT: Expression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway

ORGANISM(S): Drosophila melanogaster  



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Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.

Flaherty Maria Sol MS   Zavadil Jiri J   Ekas Laura A LA   Bach Erika A EA  

Developmental dynamics : an official publication of the American Association of Anatomists 20090901 9

Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT target genes. Genome-wide expression profiling on eye discs in which Stat92E is hyperactivated, revealed 584 differentially regulated genes, including known targets domeless, socs36E, and wingless. Ot  ...[more]

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