Genomics

Dataset Information

59

Homo sapiens


ABSTRACT: Expression data from 'naïve' and HVC-replicon containing Huh7 cells (Clone A cells)

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA116979 | ENA |

REPOSITORIES: ENA

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Publications


Three cyclophilin inhibitors (DEBIO-025, SCY635, and NIM811) are currently in clinical trials for hepatitis C therapy. The mechanism of action of these, however, is not completely understood. There are at least 16 cyclophilins expressed in human cells which are involved in a diverse set of cellular processes. Large-scale siRNA experiments, chemoproteomic assays with cyclophilin binding compounds, and mRNA profiling of HCV replicon containing cells were used to identify the cyclophilins that are  ...[more]

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