Dataset Information


Streptococcus pyogenes

ABSTRACT: S. pyogenes wild type vs. CvfA- mutant

ORGANISM(S): Streptococcus pyogenes  



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Virulence gene regulation by CvfA, a putative RNase: the CvfA-enolase complex in Streptococcus pyogenes links nutritional stress, growth-phase control, and virulence gene expression.

Kang Song Ok SO   Caparon Michael G MG   Cho Kyu Hong KH  

Infection and immunity 20100412 6

Streptococcus pyogenes, a multiple-auxotrophic human pathogen, regulates virulence gene expression according to nutritional availability during various stages in the infection process or in different infection sites. We discovered that CvfA influenced the expression of virulence genes according to growth phase and nutritional status. The influence of CvfA in C medium, rich in peptides and poor in carbohydrates, was most pronounced at the stationary phase. Under these conditions, up to 30% of the  ...[more]

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