Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Differentially expressed genes after treatment with hydroxytyrosol in DMBA-induced rat breast tumors

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA116997 | ENA |

REPOSITORIES: ENA

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Publications

Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.

Granados-Principal Sergio S   Quiles Jose L JL   Ramirez-Tortosa Cesar C   Camacho-Corencia Pedro P   Sanchez-Rovira Pedro P   Vera-Ramirez Laura L   Ramirez-Tortosa M Carmen MC  

Molecular nutrition & food research 20101201


SCOPE: Hydroxytyrosol (a phenolic compound derived from virgin olive oil) has demonstrated an anti-tumour effect in several tumour cell lines in addition to other health-related properties. The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of hydroxytyrosol and to discover which pathways are modified by hydroxytyrosol. METHODS AND RESULTS: Dimethylbenz[α]anthracene-induced mammary tumours were induced in 28  ...[more]

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