Dataset Information


Homo sapiens

ABSTRACT: Determining lovastatin-induced differences in expression between statin sensitive and insensitive MM cells

ORGANISM(S): Homo sapiens  



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Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma.

Clendening James W JW   Pandyra Aleksandra A   Li Zhihua Z   Boutros Paul C PC   Martirosyan Anna A   Lehner Richard R   Jurisica Igor I   Trudel Suzanne S   Penn Linda Z LZ  

Blood 20100401 23

Statin inhibitors, used to control hypercholesterolemia, trigger apoptosis of hematologic tumor cells and therefore have immediate potential as anticancer agents. Evaluations of statins in acute myelogenous leukemia and multiple myeloma have shown that statin efficacy is mixed, with only a subset of tumor cells being highly responsive. Our goal was to distinguish molecular features of statin-sensitive and -insensitive myeloma cells and gain insight into potential predictive markers. We show that  ...[more]

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