Dataset Information


Drosophila melanogaster

ABSTRACT: Effects of chronic hypoxia on Duchenne Muscular Dystrophy Drosophila melanogaster model

ORGANISM(S): Drosophila melanogaster  



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Chronic hypoxia impairs muscle function in the Drosophila model of Duchenne's muscular dystrophy (DMD).

Mosqueira Matias M   Willmann Gabriel G   Ruohola-Baker Hannele H   Khurana Tejvir S TS  

PloS one 20101020 10

Duchenne's muscular dystrophy (DMD) is a severe progressive myopathy caused by mutations in the DMD gene leading to a deficiency of the dystrophin protein. Due to ongoing muscle necrosis in respiratory muscles late-stage DMD is associated with respiratory insufficiency and chronic hypoxia (CH). To understand the effects of CH on dystrophin-deficient muscle in vivo, we exposed the Drosophila model for DMD (dmDys) to CH during a 16-day ascent to the summit of Mount Denali/McKinley (6194 meters abo  ...[more]

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