Genomics

Dataset Information

0

Gallus gallus


ABSTRACT: Gene expression profile of embryonic retinas expressing c-hairy1, Delta-1, or Wnt2b

ORGANISM(S): Gallus gallus  

PROVIDER: PRJNA117115 | ENA |

REPOSITORIES: ENA

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Publications

Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.

Kubo Fumi F   Nakagawa Shinichi S  

Development (Cambridge, England) 20090422 11


In the vertebrate retina, stem cell-like progenitor cells are maintained in a distinct region called the ciliary marginal zone (CMZ). Canonical Wnt signaling regulates the maintenance of the progenitor cells in the CMZ. However, its downstream molecular mechanisms have remained largely unclear. Here, we show that chick Hairy1, an established Notch signaling effector, mediates the Wnt-dependent maintenance of CMZ progenitor cells in chicken. Interestingly, unlike other developmental contexts in w  ...[more]

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