Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA117137 | ENA |

REPOSITORIES: ENA

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Publications


To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, Alox15 encoding the protein 12/15 lipoxygenase (LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we established transgenic mice that overexpressed 12/15-LOX in cardiomyocytes. Echocardiography showed that Alox15 transgenic mice developed systolic dysfunction. Cardiac fibrosis increas  ...[more]

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