Dataset Information


Mus musculus

ABSTRACT: Expression profiling of joint tissue from C3H and interval specific congenic mouse lines post- B. burgdorferi infection

ORGANISM(S): Mus musculus  



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Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12.

Ma Ying Y   Miller Jennifer C JC   Crandall Hillary H   Larsen Eric T ET   Dunn Diane M DM   Weiss Robert B RB   Subramanian Meenakumari M   Weis John H JH   Zachary James F JF   Teuscher Cory C   Weis Janis J JJ  

Infection and immunity 20090601 8

The observation that Borrelia burgdorferi-induced arthritis is severe in C3H mice and milder in C57BL/6 (B6) mice has allowed a forward genetics approach for the identification of genetic elements that regulate the arthritis response. Quantitative trait loci (QTL) on five chromosomes (Chr) were identified previously in segregating crosses between C3H and B6 mice and collectively designated B. burgdorferi arthritis-associated (Bbaa) QTL. Reciprocal interval-specific congenic lines (ISCL) that enc  ...[more]

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