Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: E-GEOD-16992
PROVIDER: PRJNA117839 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Expression Profiling of Early Myogenesis - Illumina Dataset
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Project description:Expression Profiling of Early Myogenesis - Affymetrix Dataset
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Project description:This SuperSeries is composed of the following subset Series: GSE16992: Expression Profiling of Early Myogenesis - Affymetrix Dataset GSE17038: Expression Profiling of Early Myogenesis - Illumina Dataset Refer to individual Series
2012-03-21 | E-GEOD-17039 | biostudies-arrayexpress
Project description:Expression Profiling of Early Myogenesis - Affymetrix Dataset
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Project description:miRNA expression profiling during C2C12 myogenesis
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Project description:Genetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
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Project description:Myogenesis is governed by signalling networks whose regulations are tightly controlled in a time-dependent manner. While different protein kinases have been identified to regulate various aspects of myogenesis, knowledge on the global signalling networks and their downstream substrates during myogenesis remains incomplete. Here, we map the myogenic differentiation of C2C12 cells using mass spectrometry (MS)-based phosphoproteomics and proteomics. From these data, we infer global kinase activity and predict substrates of key kinases that are involved in myogenesis. We found that multiple mitogen-activated protein kinases (MAPKs) mark the initial wave of signalling cascades. Further phosphoproteomic and proteomic profiling with MAPK1/3 and MAPK8/9 specific inhibitions unveil their shared and distinctive roles on myogenesis.
2022-05-31 | PXD028713 | Pride
Project description:Modulating the number of muscle stems cells, called satellite cells, during early postnatal development produces long-term effects on muscle growth. We tested the hypothesis that high expression levels of the anti-aging protein Klotho in early postnatal myogenesis increase satellite cell numbers by influencing the epigenetic regulation of genes that regulate myogenesis. Our findings show that elevated klotho expression caused a transient increase in satellite cell numbers and slowed muscle fiber growth, followed by a period of accelerated muscle growth that resulted in larger fibers. Klotho also transcriptionally down-regulated the H3K27 demethylase Jmjd3, increased H3K27 methylation and decreased expression of genes in the canonical Wnt pathway, which was associated with a significant delay in muscle differentiation. In addition, Klotho stimulation and subsequent Jmjd3 down-regulation produced similar but not additive reductions in the expression of Wnt4, Wnt9a and Wnt10a in myogenic cells, indicating that inhibition occurred through a common pathway. Together, our results identify a novel pathway through which Klotho influences myogenesis by reducing expression of Jmjd3, leading to reductions in the expression of Wnt genes and inhibition of canonical Wnt signaling.
2022-04-20 | GSE189109 | GEO