Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA117959 | ENA |

REPOSITORIES: ENA

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Publications

Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation.

Griffith Ann V AV   Fallahi Mohammad M   Nakase Hiroshi H   Gosink Mark M   Young Brandon B   Petrie Howard T HT  

Immunity 20091201 6


Interaction of hematopoietic progenitors with the thymic microenvironment induces them to proliferate, adopt the T lineage fate, and asymmetrically diverge into multiple functional lineages. Progenitors at various developmental stages are stratified within the thymus, implying that the corresponding microenvironments provide distinct sets of signals to progenitors migrating between them. These differences remain largely undefined. Here we used physical and computational approaches to generate a  ...[more]

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