Dataset Information


Cryptococcus neoformans

ABSTRACT: Role of Cryptococcus neoformans Sre1-pathway in low oxygen gene expression

ORGANISM(S): Cryptococcus neoformans  



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Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.

Bien Clara M CM   Chang Yun C YC   Nes W David WD   Kwon-Chung Kyung J KJ   Espenshade Peter J PJ  

Molecular microbiology 20091008 3

In the human fungal pathogen Cryptococcus neoformans, the SREBP orthologue Sre1 is important for adaptation and growth in nutrient-limiting host tissues. In this study, we characterize the C. neoformans serotype A Sre1 and its activating protease, Stp1. We demonstrate that Stp1 is a functionally conserved orthologue of the mammalian Site-2 protease and that Stp1 cleaves Sre1 within its predicted first transmembrane segment. Gene expression analysis revealed that Stp1 is required for both Sre1-de  ...[more]

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