Project description:In this study, we used Saccharomyces cerevisiae to investigate the effects of GRX deletion on yeast chronological life span (CLS). Deletion of Grx1 or Grx2 shortened yeast CLS. Quantitative proteomics revealed that GRX deletion increased cellular ROS levels to activate Ras/PKA signal pathway. Our results provided new insights into mechanisms underlying aging process.
Project description:Transcriptional profiling of yeast transcription factor deletion strains (rox1, xbp1 or phd1) and wild-type strains in response to hydrogen peroxide or butanol
