Rattus norvegicus
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ABSTRACT:
PROVIDER: PRJNA119315 | ENA |
REPOSITORIES: ENA
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Project description:Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of the present study was to investigate alterations in gene expression patterns in the Anterior Cingulate Cortex and Nucleus Accumbens of rats self-administering cocaine and treated repeatedly with TsA, and compare them with rats taking only cocaine. We used Affymetrix microarrays to identify genes the expression of which was up-regulated or downregulated during this process.
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