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Homo sapiens

ABSTRACT: Novel treatment of human pancreatic cancer using masitinib combined with standard gemcitabine chemotherapy

ORGANISM(S): Homo sapiens  



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Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer.

Sabatier Renaud R   Finetti Pascal P   Adelaide José J   Guille Arnaud A   Borg Jean-Paul JP   Chaffanet Max M   Lane Lydie L   Birnbaum Daniel D   Bertucci François F  

PloS one 20111116 11

INTRODUCTION:ECRG4/C2ORF40 is a potential tumor suppressor gene (TSG) recently identified in esophageal carcinoma. Its expression, gene copy number and prognostic value have never been explored in breast cancer. METHODS:Using DNA microarray and array-based comparative genomic hybridization (aCGH), we examined ECRG4 mRNA expression and copy number alterations in 353 invasive breast cancer samples and normal breast (NB) samples. A meta-analysis was done on a large public retrospective gene express  ...[more]

Publication: 1/2

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