Dataset Information


Mus musculus

ABSTRACT: CAFs are activated in incipient neoplasia to orchestrate tumor promoting inflammation in an NF-κB-dependent manner.

ORGANISM(S): Mus musculus  



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Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

Erez Neta N   Truitt Morgan M   Olson Peter P   Arron Sarah Tuttleton ST   Hanahan Douglas D  

Cancer cell 20100204 2

Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion. We demonstrate that CAFs also mediate tumor-enhancing inflammation. Using a mouse model of squamous skin carcinogenesis, we found a proinflammatory gene signature in CAFs isolated from dysplastic skin. This signature was maintained in CAFs from subsequent skin carcinomas and was evident in mammary and pancreatic tumors in mice and in cognate human cancers. The inflamma  ...[more]

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