Dataset Information


Mus musculus

ABSTRACT: Gene expression profiling from memory P14 T cells with control or mutated ThPOK

ORGANISM(S): Mus musculus  



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ThPOK derepression is required for robust CD8 T cell responses to viral infection.

Setoguchi Ruka R   Taniuchi Ichiro I   Bevan Michael J MJ  

Journal of immunology (Baltimore, Md. : 1950) 20090904 7

In the thymus, the transcription factor ThPOK is essential for the development of the CD4 helper T cell lineage, whereas active repression of ThPOK is critical for the development of the CD8 cytotoxic T cell lineage. ThPOK gene silencing is thought to be irreversible in peripheral CD8 T cells. We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role for ThPOK in the CD8 T cell response to an  ...[more]

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