Genomics

Dataset Information

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Rattus norvegicus


ABSTRACT: Estrogen-driven Prolactin-mediated Gene Expression Networks Hormone Induced Prostatic Dysplasia

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA120037 | ENA |

REPOSITORIES: ENA

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Publications

Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia.

Tam Neville N C NN   Szeto Carol Y Y CY   Freudenberg Johannes M JM   Fullenkamp Amy N AN   Medvedovic Mario M   Ho Shuk-Mei SM  

Molecular endocrinology (Baltimore, Md.) 20100922 11


Cotreatment with testosterone (T) and 17β-estradiol (E2) is an established regimen for inducing of prostatic intraepithelial neoplasia (PIN) and prostate cancer in rodent models. We previously used the pure antiestrogen ICI 182,780 (ICI) and bromocriptine, a dopamine receptor agonist, to inhibit PIN induction and systemic hyperprolactinemia in Noble rats and found that the carcinogenic action of T+E2 is mediated directly by the effects of E2 on the prostate and/or indirectly via E2-induced hyper  ...[more]

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