Dataset Information


Rattus norvegicus

ABSTRACT: Estrogen-driven Prolactin-mediated Gene Expression Networks Hormone Induced Prostatic Dysplasia

ORGANISM(S): Rattus norvegicus  



altmetric image


Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia.

Tam Neville N C NN   Szeto Carol Y Y CY   Freudenberg Johannes M JM   Fullenkamp Amy N AN   Medvedovic Mario M   Ho Shuk-Mei SM  

Molecular endocrinology (Baltimore, Md.) 20100922 11

Cotreatment with testosterone (T) and 17β-estradiol (E2) is an established regimen for inducing of prostatic intraepithelial neoplasia (PIN) and prostate cancer in rodent models. We previously used the pure antiestrogen ICI 182,780 (ICI) and bromocriptine, a dopamine receptor agonist, to inhibit PIN induction and systemic hyperprolactinemia in Noble rats and found that the carcinogenic action of T+E2 is mediated directly by the effects of E2 on the prostate and/or indirectly via E2-induced hyper  ...[more]

Similar Datasets

2010-05-09 | GSE17819 | GEO
2010-05-09 | E-GEOD-17819 | ArrayExpress
2008-05-24 | GSE11529 | GEO
| GSE81217 | GEO
2008-05-24 | E-GEOD-11529 | ArrayExpress
| PRJNA99949 | ENA
2009-09-30 | GSE15243 | GEO
| GSE81418 | GEO
| PRJNA403841 | ENA
| PRJNA96399 | ENA