Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and positive breast cancer

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA120039 | ENA |

REPOSITORIES: ENA

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Publications

The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer.

Calaluce Robert R   Gubin Matthew M MM   Davis J Wade JW   Magee Joseph D JD   Chen Jing J   Kuwano Yuki Y   Gorospe Myriam M   Atasoy Ulus U  

BMC cancer 20100406


BACKGROUND: The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and translation. Traditional methods of genome wide microarray analysis, profiling steady-state levels of mRNA, may miss important mRNA targets owing to significant posttranscriptional gene regulation by RNA binding proteins (RBPs). METHODS: The ribonomic approach, utilizing RNA immunoprecipitation hybridized to microarray (RIP-Chip),  ...[more]

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