Dataset Information


Mus musculus

ABSTRACT: FGF Receptor and Wnt-1 Signaling Cooperate in Mammary Tumorigenesis

ORGANISM(S): Mus musculus  



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Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.

Pond Adam C AC   Herschkowitz Jason I JI   Schwertfeger Kathryn L KL   Welm Bryan B   Zhang Yiqun Y   York Brian B   Cardiff Robert D RD   Hilsenbeck Susan S   Perou Charles M CM   Creighton Chad J CJ   Lloyd Richard E RE   Rosen Jeffrey M JM  

Cancer research 20100525 12

Fibroblast growth factor (FGF) cooperates with the Wnt/beta-catenin pathway to promote mammary tumorigenesis. To investigate the mechanisms involved in FGF/Wnt cooperation, we genetically engineered a model of inducible FGF receptor (iFGFR) signaling in the context of the well-established mouse mammary tumor virus-Wnt-1 transgenic mouse. In the bigenic mice, iFGFR1 activation dramatically enhanced mammary tumorigenesis. Expression microarray analysis did not show transcriptional enhancement of W  ...[more]

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