Genomics

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ABSTRACT: Expression data from B6C3F1 mice treated with 2-butoxyethanol and reduced oxygen

PROVIDER: PRJNA120059 | ENA |

REPOSITORIES: ENA

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To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that induces hemangiosarcomas in mice. We hypothesized that the hemolysis induced by 2-BE would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hema  ...[more]

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