Dataset Information


Campylobacter jejuni

ABSTRACT: Transcriptional profile in low to high-level macrolide resistant C. jejuni strain selected from NCTC 11168

ORGANISM(S): Campylobacter jejuni  



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Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni.

Hao Haihong H   Yuan Zonghui Z   Shen Zhangqi Z   Han Jing J   Sahin Orhan O   Liu Peng P   Zhang Qijing Q  

Antimicrobial agents and chemotherapy 20121228 3

Macrolide antibiotics are important for clinical treatment of infections caused by Campylobacter jejuni. Development of resistance to this class of antibiotics in Campylobacter is a complex process, and the dynamic molecular changes involved in this process remain poorly defined. Multiple lineages of macrolide-resistant mutants were selected by stepwise exposure of C. jejuni to escalating doses of erythromycin or tylosin. Mutations in target genes were determined by DNA sequencing, and the dynam  ...[more]

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