Genomics

Dataset Information

0

Mus musculus


ABSTRACT: WT vs. PPARd-/- Macrophages

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA120075 | ENA |

REPOSITORIES: ENA

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Publications


Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigens. Although factors participating in recognition and engulfment of apoptotic cells have been identified, the transcriptional basis for the sensing and the silent disposal of apoptotic cells is unknown. Here we show that peroxisome proliferator-activated receptor-delta (PPAR-delta) is induced when macrophages engulf apoptotic cells and functions as  ...[more]

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