Genomics

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Pervasive subtypes of pancreatic ductal adenocarcinoma (PDA) and their differing response to therapy.


ABSTRACT: Pervasive subtypes of pancreatic ductal adenocarcinoma (PDA) and their differing response to therapy.

PROVIDER: PRJNA120077 | ENA |

REPOSITORIES: ENA

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Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6 months from diagnosis. Numerous phase 3 trials of agents effective in other malignancies have failed to benefit unselected PDA populations, although patients do occasionally respond. Studies in other solid tumors have shown that heterogeneity in response is determined, in part, by molecular differences between tumors. Furthermore, treatment outcomes are improved by targeting drugs to tumor subtypes in whi  ...[more]

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