Dataset Information


Mus musculus

ABSTRACT: Abdominal Aortic Aneurysm in the ApoE Knockout Mouse: Time Course of Control vs. Angiotensin II

ORGANISM(S): Mus musculus  



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Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.

Spin Joshua M JM   Hsu Mark M   Azuma Junya J   Tedesco Maureen M MM   Deng Alicia A   Dyer Justin S JS   Maegdefessel Lars L   Dalman Ronald L RL   Tsao Philip S PS  

Physiological genomics 20110628 17

We sought to characterize temporal gene expression changes in the murine angiotensin II (ANG II)-ApoE-/- model of abdominal aortic aneurysm (AAA). Aortic ultrasound measurements were obtained over the 28-day time-course. Harvested suprarenal aortic segments were evaluated with whole genome expression profiling at 7, 14, and 28 days using the Agilent Whole Mouse Genome microarray platform and Statistical Analysis of Microarrays at a false discovery rate of <1%. A group of angiotensin-treated mice  ...[more]

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