Dataset Information


Homo sapiens

ABSTRACT: Androgen Regulated Genes in Intact Human Prostate Tissues: Relation to Benign Prostatic Hyperplasia and Prostate Cancer

ORGANISM(S): Homo sapiens  



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Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer.

Love Harold D HD   Booton S Erin SE   Boone Braden E BE   Breyer Joan P JP   Koyama Tatsuki T   Revelo Monica P MP   Shappell Scott B SB   Smith Jeffrey R JR   Hayward Simon W SW  

PloS one 20091221 12

Benign prostatic hyperplasia (BPH) and prostate carcinoma (CaP) are linked to aging and the presence of androgens, suggesting that androgen regulated genes play a major role in these common diseases. Androgen regulation of prostate growth and development depends on the presence of intact epithelial-stromal interactions. Further, the prostatic stroma is implicated in BPH. This suggests that epithelial cell lines are inadequate to identify androgen regulated genes that could contribute to BPH and  ...[more]

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