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ABSTRACT: MicroRNAs and gene expression profiles of rapamycin sensitive and resistant myogenic tumor cell line



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Reprogramming of the microRNA transcriptome mediates resistance to rapamycin.

Totary-Jain Hana H   Sanoudou Despina D   Ben-Dov Iddo Z IZ   Dautriche Cula N CN   Guarnieri Paolo P   Marx Steven O SO   Tuschl Thomas T   Marks Andrew R AR  

The Journal of biological chemistry 20130108 9

The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation that is often deregulated in cancer. Inhibitors of mTOR, including rapamycin and its analogues, are being evaluated as antitumor agents. For their promise to be fulfilled, it is of paramount importance to identify the mechanisms of resistance and develop novel therapies to overcome it. Given the emerging role of microRNAs (miRNAs) in tumorigenesis, we hypothesized that miRNAs could play important roles in the r  ...[more]

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