Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Molecular basis for vulnerability to mitochondrial and oxidative stress in an insulinoma cell line

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA120183 | ENA |

REPOSITORIES: ENA

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Publications

Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.

Chandiramani Natasha N   Wang Xianhong X   Margeta Marta M  

PloS one 20110104 1


Many age-associated disorders (including diabetes, cancer, and neurodegenerative diseases) are linked to mitochondrial dysfunction, which leads to impaired cellular bioenergetics and increased oxidative stress. However, it is not known what genetic and molecular pathways underlie differential vulnerability to mitochondrial dysfunction observed among different cell types.Starting with an insulinoma cell line as a model for a neuronal/endocrine cell type, we isolated a novel subclonal line (named  ...[more]

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