Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA120185 | ENA |

REPOSITORIES: ENA

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Publications

Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome.

Beleut Manfred M   Zimmermann Philip P   Baudis Michael M   Bruni Nicole N   Bühlmann Peter P   Laule Oliver O   Luu Van-Duc VD   Gruissem Wilhelm W   Schraml Peter P   Moch Holger H  

BMC cancer 20120723


BACKGROUND: Renal cell carcinoma (RCC) is characterized by a number of diverse molecular aberrations that differ among individuals. Recent approaches to molecularly classify RCC were based on clinical, pathological as well as on single molecular parameters. As a consequence, gene expression patterns reflecting the sum of genetic aberrations in individual tumors may not have been recognized. In an attempt to uncover such molecular features in RCC, we used a novel, unbiased and integrative approac  ...[more]

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