Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Multinucleated Tartrate Resistant Acid Phosphatase Positive Cells with Macrophage and Osteoclast Phenotypes in Bone

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA120187 | ENA |

REPOSITORIES: ENA

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Publications

Isolation and phenotypic characterization of a multinucleated tartrate-resistant acid phosphatase-positive bone marrow macrophage.

Karlström Erik E   Ek-Rylander Barbro B   Wendel Mikael M   Andersson Göran G  

Experimental hematology 20101231 3


Prothrombin (PT) and osteopontin (OPN) promote adhesion of bone-derived tartrate-resistant acid phosphatase (TRAP, Acp5)-positive multinucleated cells differing in size, morphology, and resorptive activity. Here we explored phenotypic and functional differences between these cells.Global-wide and TRAP (Acp5) promoter messenger RNA expression, ability for phagocytosis, macrophage colony-stimulating factor-dependent migration, and in situ localization of these cells were investigated.Gene expressi  ...[more]

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