Genomics

Dataset Information

235

Mus musculus


ABSTRACT: Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine prostate tumors

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA120215 | ENA |

REPOSITORIES: ENA

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Publications

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

Qi Jianfei J   Nakayama Koh K   Cardiff Robert D RD   Borowsky Alexander D AD   Kaul Karen K   Williams Roy R   Krajewski Stan S   Mercola Dan D   Carpenter Philip M PM   Bowtell David D   Ronai Ze'ev A ZA  

Cancer cell 20100701 1


Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation between HIF-1alpha and FoxA2, a transcription factor expressed in NE tissue, promotes recruitment of p300 to transactivate select HIF-regulated genes, Hes6, Sox9, and Jmjd1a. These HI  ...[more]

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