Genomics

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ABSTRACT: Identification and validation of causal genes for atherosclerosis in mice

PROVIDER: PRJNA120217 | ENA |

REPOSITORIES: ENA

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Atherosclerosis represents the most significant risk factor for coronary artery disease (CAD), the leading cause of death in developed countries. To better understand the pathogenesis of atherosclerosis, we applied a likeli-hood-based model selection method to infer gene-disease causality relationships for the aortic lesion trait in a segregating mouse population demonstrating a spectrum of susceptibility to developing atherosclerotic lesions. We identified 292 genes that tested causal for aorti  ...[more]

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