Dataset Information


Caenorhabditis elegans

ABSTRACT: Comprehensive discovery of endogenous Argonaute binding sites in C. elegans

ORGANISM(S): Caenorhabditis elegans  



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Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans.

Zisoulis Dimitrios G DG   Lovci Michael T MT   Wilbert Melissa L ML   Hutt Kasey R KR   Liang Tiffany Y TY   Pasquinelli Amy E AE   Yeo Gene W GW  

Nature structural & molecular biology 20100110 2

MicroRNAs (miRNAs) regulate gene expression by guiding Argonaute proteins to specific target mRNA sequences. Identification of bona fide miRNA target sites in animals is challenging because of uncertainties regarding the base-pairing requirements between miRNA and target as well as the location of functional binding sites within mRNAs. Here we present the results of a comprehensive strategy aimed at isolating endogenous mRNA target sequences bound by the Argonaute protein ALG-1 in C. elegans. Us  ...[more]

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