Genomics,Multiomics

Dataset Information

0

Tetrahymena thermophila


ABSTRACT: Genome-Wide Microarray Analysis of Histone H2B Ubiquitylation mutant strains of Tetrahymena thermophila

OTHER RELATED OMICS DATASETS IN: E-GEOD-18743

PROVIDER: PRJNA121657 | ENA |

REPOSITORIES: ENA

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Publications

Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena.

Wang Zhe Z   Cui Bowen B   Gorovsky Martin A MA  

The Journal of biological chemistry 20091011 50


Ubiquitylation of histone H2B and/or a component of the system that ubiquitylates H2B is required for methylation of histone H3 at lysine 4 (H3K4) in yeasts and probably in humans. In this study, the single ubiquitylation site was mapped to conserved lysine 115 of the C-terminal region of histone H2B in the single-cell model organism Tetrahymena thermophila. In strains lacking H2B ubiquitylation, H3K4 methylation was not detectably affected. As in other organisms, the E2 ubiquitin-conjugating en  ...[more]

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