Genomics,Multiomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Identification of biomarkers that distinguish chemical contaminants using a gradient feature selection method

OTHER RELATED OMICS DATASETS IN: E-GEOD-19662

PROVIDER: PRJNA122565 | ENA |

REPOSITORIES: ENA

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Publications

In vitro gene regulatory networks predict in vivo function of liver.

Deng Youping Y   Johnson David R DR   Guan Xin X   Ang Choo Y CY   Ai Junmei J   Perkins Edward J EJ  

BMC systems biology 20101112


<h4>Background</h4>Evolution of toxicity testing is predicated upon using in vitro cell based systems to rapidly screen and predict how a chemical might cause toxicity to an organ in vivo. However, the degree to which we can extend in vitro results to in vivo activity and possible mechanisms of action remains to be fully addressed.<h4>Results</h4>Here we use the nitroaromatic 2,4,6-trinitrotoluene (TNT) as a model chemical to compare and determine how we might extrapolate from in vitro data to i  ...[more]

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