Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Sty2 SNP array

OTHER RELATED OMICS DATASETS IN: GSE15347

PROVIDER: PRJNA123005 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Homo sapiens

Project description:Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Nsp SNP Array

| PRJNA123003 | ENA

Homo sapiens

Project description:Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Hind SNP array

| PRJNA122987 | ENA

Homo sapiens

Project description:Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Xba SNP array

| PRJNA123007 | ENA

Homo sapiens

Project description:Affymetrix U133A array data for 111 pediatric acute myeloid leukemia (AML) samples at diagnosis

| PRJNA123171 | ENA

Homo sapiens

Project description:Affymetrix SNP array data for acute myeloid leukemia samples

| PRJNA377277 | ENA

Project description:Analysis of pediatric acute myeloid leukemia (AML) samples at diagnosis

| PRJNA116577 | ENA

Homo sapiens

Project description:Affymetrix SNP array data for acute myeloid leukemia (AML) samples with complex karyotype

| PRJNA164717 | ENA

Affymetrix SNP array data for a pediatric acute lymphoblastic leukemia samples

Project description:Affymetrix SNP array data for a pediatric acute lymphoblastic leukemia samples

| PRJNA506710 | ENA

High-Resolution Genomic Profiling of Adult and Pediatric Core-Binding-Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Alterations

Project description:To identify cooperating lesions in core-binding-factor acute myeloid leukemia (CBF-AML), we performed single-nucleotide polymorphism (SNP)-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. We identified a mean of 1.28 copy number alterations (CNAs) per case at diagnosis in both patient populations. Recurrent minimally deleted regions (MDRs) were identified at 7q36.1 (7.7%), 9q21.13 (5%), 11p13 (2.3%), and 17q11.2 (2%). Recurrent focal gains were identified at 8q24.21 (4.7%) and 11q25 (1.7%), both containing a single non-coding RNA. Recurrent regions of copy-neutral loss-of-heterozygosity were identified at 1p (1%), 4q (0.7%), and 19p (0.7%), with known mutated cancer genes present in the minimally altered region. Analysis of relapse samples identified recurrent MDRs at 3q13 (12.2%), 5q (4.9%), and 17p (4.9%). SNP genotyping was performed on 300 adult and pediatric CBF-AMLs; t(8;21), n=157 (adult, n=114; pediatric, n=43); and inv(16), n=143 (adult, n=104; pediatric, n=39). Germline control DNA from remission bone marrow or peripheral blood was available for paired analysis in 175 patients. In addition, for 41 patients, matched relapse samples were analyzed. Data were processed using reference alignment, dChipSNP and circular binary segmentation.

2012-02-07 | E-GEOD-32462 | biostudies-arrayexpress

High-Resolution Genomic Profiling of Adult and Pediatric Core-Binding-Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Alterations

2012-02-07 | GSE32462 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data