Dataset Information


Homo sapiens

ABSTRACT: Profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression

ORGANISM(S): Homo sapiens  



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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Barbie David A DA   Tamayo Pablo P   Boehm Jesse S JS   Kim So Young SY   Moody Susan E SE   Dunn Ian F IF   Schinzel Anna C AC   Sandy Peter P   Meylan Etienne E   Scholl Claudia C   Fröhling Stefan S   Chan Edmond M EM   Sos Martin L ML   Michel Kathrin K   Mermel Craig C   Silver Serena J SJ   Weir Barbara A BA   Reiling Jan H JH   Sheng Qing Q   Gupta Piyush B PB   Wadlow Raymond C RC   Le Hanh H   Hoersch Sebastian S   Wittner Ben S BS   Ramaswamy Sridhar S   Livingston David M DM   Sabatini David M DM   Meyerson Matthew M   Thomas Roman K RK   Lander Eric S ES   Mesirov Jill P JP   Root David E DE   Gilliland D Gary DG   Jacks Tyler T   Hahn William C WC  

Nature 20091021 7269

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has remained refractory to this approach. A complementary strategy for targeting KRAS is to identify gene products that, when inhibited, result in cell death only in the presence of an oncogenic allele. Here  ...[more]

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