Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos -13 somites embryonic stage

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA123383 | ENA |

REPOSITORIES: ENA

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Publications


Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant phenotypes. Conversely, posterior (paralog group 13) Hox genes can prematurely arrest posterior axial growth when precociously expressed. Our data suggest that the transition from trunk to tail Hox gene expr  ...[more]

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