Genomics

Dataset Information

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Rattus norvegicus


ABSTRACT: Modulation of gene expression by rapamycin in hepatic cell lines, WB-F344 and WB311

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA123385 | ENA |

REPOSITORIES: ENA

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Publications

Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines.

Jimenez Rosa H RH   Boylan Joan M JM   Lee Ju-Seog JS   Francesconi Mirko M   Castellani Gastone G   Sanders Jennifer A JA   Gruppuso Philip A PA  

PloS one 20091009 10


The mTOR inhibitor rapamycin has anti-tumor activity across a variety of human cancers, including hepatocellular carcinoma. However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin responsiveness would show common characteristics accounting for resistance to the drug.We profiled a total of 13 cell lines for rapamycin-induced growth inhibition. The non-tumorigenic rat liver epithelial cell line WB-F344 was highly sensitive whil  ...[more]

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