Dataset Information


Homo sapiens

ABSTRACT: Inflammatory gene profiling of Ewing sarcoma family of tumors (set B)

ORGANISM(S): Homo sapiens  



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High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients.

Savola Suvi S   Klami Arto A   Myllykangas Samuel S   Manara Cristina C   Scotlandi Katia K   Picci Piero P   Knuutila Sakari S   Vakkila Jukka J  

ISRN oncology 20111002

Background. Unlike in most adult-onset cancers, an association between typical paediatric neoplasms and inflammatory triggers is rare. We studied whether immune system-related genes are activated and have prognostic significance in Ewing's sarcoma family of tumors (ESFTs). Method. Data analysis was performed on gene expression profiles of 44 ESFT patients, 11 ESFT cell lines, and 18 normal skeletal muscle samples. Differential expression of 238 inflammation and 299 macrophage-related genes was a  ...[more]

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