Dataset Information


Mus musculus

ABSTRACT: Gene expression profiles of murine granule neuron precursors and medulloblastoma

ORGANISM(S): Mus musculus  



altmetric image


Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis.

Lee Eunice Y EY   Ji Hongkai H   Ouyang Zhengqing Z   Zhou Baiyu B   Ma Wenxiu W   Vokes Steven A SA   McMahon Andrew P AP   Wong Wing H WH   Scott Matthew P MP  

Proceedings of the National Academy of Sciences of the United States of America 20100511 21

Many genes initially identified for their roles in cell fate determination or signaling during development can have a significant impact on tumorigenesis. In the developing cerebellum, Sonic hedgehog (Shh) stimulates the proliferation of granule neuron precursor cells (GNPs) by activating the Gli transcription factors. Inappropriate activation of Shh target genes results in unrestrained cell division and eventually medulloblastoma, the most common pediatric brain malignancy. We find dramatic dif  ...[more]

Similar Datasets

2008-10-21 | E-GEOD-11859 | ArrayExpress
2008-06-24 | GSE11859 | GEO
| GSE107252 | GEO
2012-07-12 | E-GEOD-34100 | ArrayExpress
| PRJNA323505 | ENA
2013-09-27 | E-GEOD-51219 | ArrayExpress
| PRJNA123279 | ENA
2012-07-12 | E-GEOD-34050 | ArrayExpress
2012-07-13 | GSE34050 | GEO
| PRJNA105663 | ENA