Genomics

Dataset Information

294

Mus musculus


ABSTRACT: Gene expression profiles of murine granule neuron precursors and medulloblastoma

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA123397 | ENA |

REPOSITORIES: ENA

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Publications

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis.

Lee Eunice Y EY   Ji Hongkai H   Ouyang Zhengqing Z   Zhou Baiyu B   Ma Wenxiu W   Vokes Steven A SA   McMahon Andrew P AP   Wong Wing H WH   Scott Matthew P MP  

Proceedings of the National Academy of Sciences of the United States of America 20100511 21


Many genes initially identified for their roles in cell fate determination or signaling during development can have a significant impact on tumorigenesis. In the developing cerebellum, Sonic hedgehog (Shh) stimulates the proliferation of granule neuron precursor cells (GNPs) by activating the Gli transcription factors. Inappropriate activation of Shh target genes results in unrestrained cell division and eventually medulloblastoma, the most common pediatric brain malignancy. We find dramatic dif  ...[more]

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