Dataset Information


Mus musculus

ABSTRACT: Expression analysis on Mll1+/+ and Mll1-/- MEFs

ORGANISM(S): Mus musculus  



altmetric image


Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

Wang Pengfei P   Lin Chengqi C   Smith Edwin R ER   Guo Hong H   Sanderson Brian W BW   Wu Min M   Gogol Madelaine M   Alexander Tara T   Seidel Christopher C   Wiedemann Leanne M LM   Ge Kai K   Krumlauf Robb R   Shilatifard Ali A  

Molecular and cellular biology 20090824 22

A common landmark of activated genes is the presence of trimethylation on lysine 4 of histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is the only H3K4 methylase in Saccharomyces cerevisiae; however, in mammals, at least six H3K4 methylases, Set1A and Set1B and MLL1 to MLL4, are found in COMPASS-like complexes capable of methylating H3K4. To gain further insight into the different roles and functional targets for the H3K4 methylases, we have undertaken a genome-wid  ...[more]

Similar Datasets

2009-10-20 | E-GEOD-18258 | ArrayExpress
2014-06-27 | E-GEOD-49179 | ArrayExpress
2004-01-02 | GSE887 | GEO
2010-10-28 | GSE24964 | GEO
2009-10-20 | GSE18261 | GEO
2011-01-06 | GSE21746 | GEO
2009-10-20 | E-GEOD-18261 | ArrayExpress
2014-12-04 | E-GEOD-61417 | ArrayExpress
| PRJNA123517 | ENA
2009-10-20 | GSE18264 | GEO