Dataset Information


Homo sapiens

ABSTRACT: The effect of IFNα on human CD8 T cells_with other concomitant signals

ORGANISM(S): Homo sapiens  



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Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells.

Hervas-Stubbs Sandra S   Riezu-Boj Jose-Ignacio JI   Gonzalez Iranzu I   Mancheño Uxua U   Dubrot Juan J   Azpilicueta Arantza A   Gabari Izaskun I   Palazon Asis A   Aranguren Alicia A   Ruiz Juan J   Prieto Jesus J   Larrea Esther E   Melero Ignacio I  

European journal of immunology 20101201 12

IFN-α/β link innate and adaptive immune responses by directly acting on naïve CD8(+) T cells. This concept unveiled in mice remains unexplored in humans. To investigate that, human CD8(+) CD45RO(-) cells were stimulated with beads coated with anti-CD3 and anti-CD28 mAb, mimicking Ag (type-1) and co-stimulatory (type-2) signals, in the presence or absence of IFN-α and their transcriptional profiles were defined by cDNA-microarrays. We show that IFN-α provides a strong third signal directly to hum  ...[more]

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