Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: The effect of IFNα on human CD8 T cells_with other concomitant signals

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA123599 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells.

Hervas-Stubbs Sandra S   Riezu-Boj Jose-Ignacio JI   Gonzalez Iranzu I   Mancheño Uxua U   Dubrot Juan J   Azpilicueta Arantza A   Gabari Izaskun I   Palazon Asis A   Aranguren Alicia A   Ruiz Juan J   Prieto Jesus J   Larrea Esther E   Melero Ignacio I  

European journal of immunology 20101201 12


IFN-α/β link innate and adaptive immune responses by directly acting on naïve CD8(+) T cells. This concept unveiled in mice remains unexplored in humans. To investigate that, human CD8(+) CD45RO(-) cells were stimulated with beads coated with anti-CD3 and anti-CD28 mAb, mimicking Ag (type-1) and co-stimulatory (type-2) signals, in the presence or absence of IFN-α and their transcriptional profiles were defined by cDNA-microarrays. We show that IFN-α provides a strong third signal directly to hum  ...[more]

Similar Datasets

2010-07-23 | E-GEOD-17302 | ArrayExpress
| PRJNA123601 | ENA
2007-01-01 | S-EPMC2531291 | BioStudies
2013-01-01 | S-EPMC3743458 | BioStudies
2012-01-01 | S-EPMC3571422 | BioStudies
1000-01-01 | S-EPMC2374701 | BioStudies
2020-01-01 | S-EPMC7060673 | BioStudies
1000-01-01 | S-EPMC1690963 | BioStudies
2010-09-25 | GSE24338 | GEO
2012-01-01 | S-EPMC3284330 | BioStudies