Dataset Information


Mus musculus

ABSTRACT: Analysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice

ORGANISM(S): Mus musculus  



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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.

Kovalenko Andrew A   Kim Jin-Chul JC   Kang Tae-Bong TB   Rajput Akhil A   Bogdanov Konstantin K   Dittrich-Breiholz Oliver O   Kracht Michael M   Brenner Ori O   Wallach David D  

The Journal of experimental medicine 20090831 10

Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of nuclear factor kappaB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not depend on TNF, IL-1, dermal macrophage function, or expression of the toll-like receptor adapter proteins MyD88 or TRIF. Both interferon regulatory factor (IRF) 3 and TANK-binding kinase  ...[more]

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